An efficient one-pot approach to phenanthrene derivatives using a catalyzed tandem Ullmann-pinacol coupling reaction

作者：Lin Shuang zheng; You Tian pa^*

来源：Tetrahedron, 2008, 64(42): 9906-9910.

DOI：10.1016/j.tet.2008.08.004

• tandem catalysis
• Ullmann-pinacol reaction
• 9,10-dihydrophenanthrene-9,10-diols
• 9-phenanthrols

In the presence of catalyst (Ph(3)P)(2)NiCl(2) and reductant Zn, the Ullmann reactions of ortho-halo aryl aldehydes generate biaryl-dialdehydes and zinc halides. Subsequently, ZnX(2) can catalyze the intramolecular pinacol coupling reaction of biaryl-dialdehydes to form 9,10-dihydrophenanthrene-9,10-diols. One-pot synthesis of 9-phenanthrols can be achieved using this strategy.

• 出版日期2008-10-13