Memory vs memory-like: The different facets of CD8(+) T-cell memory in HCV infection

作者：Hofmann Maike; Wieland Dominik; Pircher Hanspeter; Thimme Robert^*

来源：Immunological Reviews, 2018, 283(1): 232-237.

DOI：10.1111/imr.12642

• HCV
• human viral infection
• memory-like CD8(+) T cells
• T-cell exhaustion
• viral escape

Memory CD8(+) T cells are essential in orchestrating protection from re-infection. Hallmarks of virus-specific memory CD8(+) T cells are the capacity to mount recall responses with rapid induction of effector cell function and antigen-independent survival. Growing evidence reveals that even chronic infection does not preclude virus-specific CD8(+) T-cell memory formation. However, whether this kind of CD8(+) T-cell memory that is established during chronic infection is indeed functional and provides protection from re-infection is still unclear. Human chronic hepatitis C virus infection represents a unique model system to study virus-specific CD8(+) T-cell memory formation during and after cessation of persisting antigen stimulation.

• 出版日期2018-5