Altered EEG resting-state effective connectivity in drug-naive childhood absence epilepsy

作者：Rotondi Fabio; Franceschetti Silvana; Avanzini Giuliano; Panzica Ferruccio^*

来源：Clinical Neurophysiology, 2016, 127(2): 1130-1137.

DOI：10.1016/j.clinph.2015.09.003

• EEG
• Absence epilepsy
• Resting state
• PDC
• Effective connectivity

Objective: We investigated interictal EEG activity in patients with childhood absence seizures with the aim of detecting markers of network defects generating "idiopathic" hyperexcitability in this form of epilepsy.
Methods: We included 11 edrug-naive patients with childhood absence epilepsy (CAE), and 11 age matched controls (CTRL). We analyzed interictal EEG using partial directed coherence (PDC), a connectivity estimator in frequency domain based on autoregressive multivariate (MVAR) modeling giving the advantage of indicating the direction and strength of the interactions between multiple variables.
Results: Our results revealed the presence of an abnormal cortico-cortical network occurring in the interictal condition in CAE and involving a large span of frequencies, with prominence in the alpha band; the most evident finding was a highly significant increase of out-going connectivity involving frontal and central cortical areas in CAE patients compared to CTRL subjects.
Conclusions: Our observation indicates that, in interictal conditions, a distorted network characterizes CAE, and a hyperconnected network is already detectable under resting conditions in the delta, theta and alpha bands.
Significance: The increased interictal EEG connectivity demonstrated here provides support for a persistent abnormal relationship between the thalamus and a hyperexcitable cortex outside the ictal phase.

• 出版日期2016-2