A New Dibenzocyclooctadiene Lignan from the Stems of Schisandra neglecta and It Cytotoxicities

作者:Ye Yan Qing; Xia Cong Fang; Li Yin Ke; Wu Xian Xue; Du Gang; Hu Qiu Fen; Gao Xue Mei*
来源:Asian Journal of Chemistry, 2014, 26(7): 1948-1950.
DOI:10.14233/ajchem.2014.15583

摘要

A new dibenzocyclooctadiene lignan, neglignan (1) was isolated from the stems,of Schisandra neglecta. The structures of (1) was elucidated by spectroscopic methods; including extensive 1D and 2D NMR techniques, Compound 1 was tested for-ifs cytotoxicity five human tumor cell lines (NB4, A549, SHSY5Y, PC3 and MCF7) and compound 1 exhibited modest cytotoxicity against NB4, A549 and MCF7 cell With IC50 values of 8.1, 7.4 and 6.7 mu M, respectively.

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