科研之友
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摘要
Physical inactivity in youth with cerebral palsy (CP) places them at increased risk of developing cardiovascular disease. The current study assessed indices of arterial health in adolescents with CP, classified as levels I-II of the Gross Motor Function Classification System (GMFCS) ( , age ˋyr), in comparison to age- and sex-matched controls ( , age ˋyr). Groups were similar in anthropometric measurements, resting blood pressures, and heart rates. There were no group differences in brachial flow-mediated dilation ( versus ), carotid intima-media thickness ( versus ˋmm), and distensibility ( versus ˋmmHg) or central ( versus ˋm/s) and peripheral pulse wave velocity ( versus ˋm/s); CP versus healthy controls, respectively. Vigorous intensity physical activity (PA) was lower in the CP group (CP: ˋmin versus controls: ˋmin); groups were similar in light and moderate intensity PA levels. Arterial health of ambulatory youth with CP is not different from a control group despite lower vigorous PA levels. Similar studies need to examine individuals with more pronounced mobility limitations (GMFCS level III每V). 1. Introduction Cerebral Palsy (CP) is defined as a disorder of posture and movement due to a nonprogressive disturbance in the developing fetal or infant brain [1]. CP manifests as limitations in gross motor capacity [2], affecting performance in daily mobility over a lifespan [3]. Youth with CP are less physically active than their typically developing peers [4, 5] and show an inverse relationship between functional limitations and social participation [6]. Physical inactivity in youth places them at a greater risk of developing a variety of secondary health complications [7] and is also a major controllable risk factor for cardiovascular disease (CVD) [8]. It has been suggested that one mechanism by which physical activity (PA) exerts its protective effect on cardiovascular health is through positive effects on the endothelium [9], a single layer of cells responsible for the vasodilator response to increased conduit artery flow. A strong relationship between low levels of PA and endothelial dysfunction has been well documented in children [10], potentially predisposing youth with CP to an increased risk of endothelial dysfunction. Endothelial dysfunction is considered an early and integral manifestation of atherosclerotic disease, which can be evident in the first decade of life [11]. Endothelial dysfunction is an indicator of preclinical vascular disease and for youth with CP may act as a marker of early changes in vessel function, indicative of
- 出版日期2012
