The Immunogenicity of Fractional Intradermal Doses of the Inactivated Poliovirus Vaccine Is Associated With the Size of the Intradermal Fluid Bleb

Bibby Jack; Saidu Yauba; Umesi Ama; Moneke Anyanwoke Ngozi; Bashorun Adedapo O; Hydara Mariama Badjie; Adigweme Ikechukwu; Adetifa Jane U; Okoye Michael; Roberts Elishia; Clemens Ralf; Bandyopadhyay Ananda S; Muhammad Abdul K; Mulwa Sarah; Royals Michael; Jarrahian Courtney; Jeffries David; Kampmann Beate; Clarke Ed<sup>*</sup>

doi:10.1093/cid/cix381

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The Immunogenicity of Fractional Intradermal Doses of the Inactivated Poliovirus Vaccine Is Associated With the Size of the Intradermal Fluid Bleb

作者：Bibby Jack; Saidu Yauba; Umesi Ama; Moneke Anyanwoke Ngozi; Bashorun Adedapo O; Hydara Mariama Badjie; Adigweme Ikechukwu; Adetifa Jane U; Okoye Michael; Roberts Elishia; Clemens Ralf; Bandyopadhyay Ananda S; Muhammad Abdul K; Mulwa Sarah; Royals Michael; Jarrahian Courtney; Jeffries David; Kampmann Beate; Clarke Ed^*

来源：Clinical Infectious Diseases, 2017, 65(5): 851-854.

DOI：10.1093/cid/cix381

摘要

The immunogenicity of fractional (one-fifth, 0.1 mL) intradermal doses of the inactivated poliovirus vaccine (ID fIPV) is positively correlated with the size of the intradermal fluid bleb. Training of vaccinators for campaign and routine ID fIPV administration should focus on generating an 8- to 10-mm bleb with each injection.