Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon

作者：Tauchen Jan; Bortl Ludvik; Huml Lukas; Miksatkova Petra; Noskocil Ivo; Marsik Petr; Villegas Pablo Pedro Panduro; Flores Ymber Bendezu; Van Damme Patrick; Lojka Bohdan; Havlik Jaroslav; Lapcik Oldrich; Kokoska Ladislav^*

来源：Brazilian Journal of Pharmacognosy, 2016, 26(6): 728-737.

DOI：10.1016/j.bjp.2016.03.016

• Antioxidant
• Anticarcindgenic
• Phenolic compounds
• Plant extracts

Among 23 extracts of medicinal and edible plants tested, Mauritia flexuosa L.f., Arecaceae, showed significant antioxidant ability (DPPH and ORAC = 1062.9 and 645.9 +/- 51.4 mu g TE/mg extract, respectively), while Annona montana Macfad., Annonaceae, demonstrated the most promising anti-proliferative effect (IC50 for Hep-G2 and HT-29 = 2.7 and 9.0 mu g/ml, respectively). However, combinatory antioxidant/anti-proliferative effect was only detected in Oenocarpus bataua Mart., Arecaceae (DPPH = 903.8 and ORAC = 1024 mu g TE/mg extract; IC50 for Hep-G2 and HT-29 at 102.6 and 38.8 mu g/ml, respectively) and Inga edulis Mart., Fabaceae (DPPH = 337.0 and ORAC = 795.7 mu g TE/mg extract; IC50 for Hep-G2 and HT-29 at 36.3 and 57.9 mu g/ml, respectively). Phenolic content was positively correlated with antioxidant potential, however not with anti-proliferative effect. None of these extracts possessed toxicity towards normal foetal lung cells, suggesting their possible use in development of novel plant-based agents with preventive and/or therapeutic action against oxidative stress-related diseases.

• 出版日期2016-12