Differences in photoreceptor recovery among patients and between different parts of the posterior pole in Vogt-Koyanagi-Harada disease

作者：Zhou, M.; Gu, R. P.; Sun, Z.; Jiang, C. H.^*; Chang, Q.; Xu, G. Z.

来源：Eye, 2018, 32(3): 572-578.

DOI：10.1038/eye.2017.250

• VISUAL-ACUITY

Purpose To investigate the recovery of photoreceptors following the treatment in Vogt-Koyanagi-Harada (VKH) disease. @@@ Patients and methods This was a retrospective study. We enrolled 28 patients with VKH (56 eyes). The clinical and optical coherence tomography (OCT) findings were recorded for 12 months after treatment. The patterns of photoreceptor recovery on OCT were defined: pattern F group=Foveal photoreceptor recovery visible first; pattern E group=Extrafoveal photoreceptor recovery visible first; and pattern S group=Simultaneous foveal and extrafoveal photoreceptor recovery. @@@ Results Photoreceptor recovery varied in different parts of the fundus among patients. Among the 56 eyes, the ellipsoid zone (EZ) recovery of 10 eyes and the interdigitation zone (IZ) recovery of 17 eyes belonged to pattern F group. In most eyes (46 eyes for EZ and 26 eyes for IZ), the recovery of these structures were pattern S. Only in 10 eyes, the recovery of IZ was pattern E. The different patterns of recovery correlated with how promptly the patients had been treated and with the anatomical and visual outcomes at 12 months. Patients in pattern F group were characterized by delayed treatment, delayed recovery of EZ or IZ, and a less favourable prognosis at 12 months relative to other patients, while those in pattern E group had the most prompt treatment and recovery as well as a more favourable outcome at 12 months. @@@ Conclusions In VKH patients with delayed treatment, foveal photoreceptors tended to recover more rapidly than photoreceptors in other regions.

• 出版日期2018-3
• 单位复旦大学