Determining the In Vivo Transverse Relaxation Time of GABA in the Human Brain at 7T

作者：Intrapiromkul Jarunee; Zhu He; Cheng Ying; Barker Peter B; Edden Richard A E^*

来源：Journal of Magnetic Resonance Imaging, 2013, 38(5): 1224-1229.

DOI：10.1002/jmri.23979

• GABA
• transverse relaxation
• T-2
• editing
• 7T
• magnetic resonance spectroscopy

PurposeTo measure in vivo transverse relaxation times (T-2) of gamma-aminobutyric acid (GABA) at 7T using the experimental spectral-editing method.
Materials and MethodsExperiments were performed at 7T in a 10 mM GABA phantom to determine the intrinsic TE-dependence of the edited signal. Then the same method was applied with editing-based suppression of coedited macromolecular signals to five healthy volunteers to determine T-2 of GABA in vivo.
ResultsFrom in vivo data acquired at multiple echo times, the in vivo GABA T-2 relaxation time was estimated to be 63 19 msec.
ConclusionWe present a measurement of the T-2 of edited GABA signal at 7T by first using phantom measurements to determine the echo time-dependence of edited signal. The method is purely experimental and does not rely on prior knowledge of coupling constants or simulation of realistic experiments. J. Magn. Reson. Imaging 2013;38:1224-1229.

• 出版日期2013-11