Association of the Alzheimer's Disease Clusterin Risk Allele with Plasma Clusterin Concentration

作者：Schuermann Britta; Wiese Birgitt; Bickel Horst; Weyerer Siegfried; Riedel Heller Steffi G; Pentzek Michael; Bachmann Cadja; Williams Julie; van den Bussche Hendrik; Maier Wolfgang; Jessen Frank^*

来源：Journal of Alzheimer's Disease, 2011, 25(3): 421-424.

DOI：10.3233/JAD-2011-110251

• Alzheimer's disease
• clusterin
• genome wide association study
• risk gene

A variant within the clusterin gene has been recently associated with increased risk for Alzheimer's disease (AD) in genome wide association studies. Here we tested the association of the respective single nucleotide polymorphisms (rs11136000) with plasma concentration of clusterin in 67 AD subjects and 191 cognitively unimpaired elderly individuals. We observed an association of the rs11136000 AD-risk variant with low clusterin plasma levels in an allele-dose dependent manner in the healthy individuals (p = 0.011). This effect was numerically also present in the AD patients. We conclude that the rs11136000 AD-risk variant is associated with low clusterin plasma levels.

• 出版日期2011
• 单位上海市精神卫生中心