Mechanism of the eosinophilic differentiation of HL-60 clone 15 cells induced by n-butyrate

作者：Ishihara K; Hong JJ; Zee O; Ohuchi K^*

来源：International Archives of Allergy and Immunology, 2005, 137: 77-82.

DOI：10.1159/000085436

• HL-60 clone 15 cells
• eosinophils
• histone acetyltransferase
• histone deacetylase
• histone deacetylase inhibitor
• n-butyrate
• apicidin
• trichostatin A

n-Butyrate is one of the most powerful chemical inducers of the differentiation of human eosinophilic leukemia HL-60 clone 15 cells into mature eosinophils. We have recently reported that the mechanism by which HL-60 clone 15 cells differentiate into eosinophils by n-butyrate is that n-butyrate continuously inhibits histone deacetylase activity as a histone deacetylase inhibitor, resulting in continuous acetylation of histones. In this review, we discuss roles of histone acetyltransferase, histone deacetylase and histone deacetylase inhibitors in the differentiation of HL-60 clone 15 cells into eosinophils.

• 出版日期2005