New therapeutic strategies in HCV: second-generation protease inhibitors

作者：Clark Virginia C; Peter Joy A; Nelson David R^*

来源：Liver International, 2013, 33(s1): 80-84.

DOI：10.1111/liv.12061

• Hepatitis C
• protease inhibitors
• ACH 2684
• MK 5172

Telaprevir and boceprevir are the first direct-acting antiviral agents approved for use in HCV treatment and represent a significant advance in HCV therapy. However, these first-generation drugs also have significant limitations related to thrice-daily dosing, clinically challenging side-effect profiles, low barriers to resistance and a lack of pan-genotype activity. A second wave of protease inhibitors are in phase II and III trials and promise to provide a drug regimen with a better dosing schedule and improved tolerance. These second-wave protease inhibitors will probably be approved in combination with PEG-IFN and Ribavirin (RBV), as well as future all-oral regimens. The true second-generation protease inhibitors are in earlier stages of development and efficacy data are anxiously awaited as they may provide pan-genotypic antiviral activity and a high genetic barrier to resistance.

• 出版日期2013-2