Neoproteoglycans in tissue engineering

作者：Weyers Amanda; Linhardt Robert J^*

来源：FEBS Journal, 2013, 280(10): 2511-2522.

DOI：10.1111/febs.12187

• biomedical scaffolds
• extracellular matrix
• glycoconjugates
• glycosaminoglycans
• growth factors
• nanocomposites
• neoproteoglycans
• proteoglycans
• regenerative medicine
• tissue engineering

Proteoglycans, comprised of a core protein to which glycosaminoglycan chains are covalently linked, are an important structural and functional family of macromolecules found in the extracellular matrix. Advances in our understanding of biological interactions have lead to a greater appreciation for the need to design tissue engineering scaffolds that incorporate mimetics of key extracellular matrix components. A variety of synthetic and semisynthetic molecules and polymers have been examined by tissue engineers that serve as structural, chemical and biological replacements for proteoglycans. These proteoglycan mimetics have been referred to as neoproteoglycans and serve as functional and therapeutic replacements for natural proteoglycans that are often unavailable for tissue engineering studies. Although neoproteoglycans have important limitations, such as limited signaling ability and biocompatibility, they have shown promise in replacing the natural activity of proteoglycans through cell and protein binding interactions. This review focuses on the recent invivo and invitro tissue engineering applications of three basic types of neoproteoglycan structures, proteinglycosaminoglycan conjugates, nano-glycosaminoglycan composites and polymerglycosaminoglycan complexes.

• 出版日期2013-5