Albumin and Hyaluronic Acid-Coated Superparamagnetic Iron Oxide Nanoparticles Loaded with Paclitaxel for Biomedical Applications

作者：Vismara Elena^*; Bongio Chiara; Coletti Alessia; Edelman Ravit; Serafini Andrea; Mauri Michele; Simonutti Roberto; Bertini Sabrina; Urso Elena; Assaraf Yehuda G; Livney Yoav D^*

来源：Molecules, 2017, 22(7): 1030.

DOI：10.3390/molecules22071030

• super paramagnetic iron oxide nanoparticles (SPION)
• hyaluronic acid (HA)
• bovine serum albumin (BSA)
• Fe3O4 center dot DA-BSA/HA
• paclitaxel (PTX)
• magnetic resonance imaging (MRI)

Super paramagnetic iron oxide nanoparticles (SPION) were augmented by both hyaluronic acid (HA) and bovine serum albumin (BSA), each covalently conjugated to dopamine (DA) enabling their anchoring to the SPION. HA and BSA were found to simultaneously serve as stabilizing polymers of Fe3O4 center dot DA-BSA/HA in water. Fe3O4 center dot DA-BSA/HA efficiently entrapped and released the hydrophobic cytotoxic drug paclitaxel (PTX). The relative amount of HA and BSA modulates not only the total solubility but also the paramagnetic relaxation properties of the preparation. The entrapping of PTX did not influence the paramagnetic relaxation properties of Fe3O4 center dot DA-BSA. Thus, by tuning the surface structure and loading, we can tune the theranostic properties of the system.

• 出版日期2017-7