The Effect of Polysaccharide K with S-1 Based Chemotherapy in Advanced Gastric Cancer

作者：Yoshikawa Kozo; Shimada Mitsuo^*; Kurita Nobuhiro; Sato Hirohiko; Iwata Takashi; Nishioka Masanori; Morimoto Shinya; Miyatani Tomohiko; Komatsu Masato; Kashihara Hideya; Takasu Chie

来源：Hepato-Gastroenterology, 2013, 60(126): 1387-1390.

DOI：10.5754/hge11355

• Polysaccharide K
• Advanced gastric cancer
• Foxp3

Background/Aims: Polysaccharide K (PSK) is widely used in Japan as a biological response modifier for cancer patients. We investigated the effects of PSK with S-1 based chemotherapy for advanced gastric cancer patients in immune response. Methodology: Nine advanced gastric cancer patients who underwent chemotherapy at the University of Tokushima were included in this study. In all patients, 3g PSK was received orally and S-1 based chemotherapy for 2 weeks alternately for 8 weeks. Serial changes in immunological parameters (Foxp3, Natural killer (NK), CD4/CD8) were monitored. Results: The levels of Foxp3 at 8 weeks was significantly decreased compared with 2 weeks (4.26% vs. 3.11%). In NK activity at 8 weeks was significantly increased compared with 2 weeks (27% vs. 47%). Conclusions: These results of this study suggested that chemotherapy with PSK improved the immune response in advanced gastric cancer patients. Especially Foxp3 was concerned in this mechanism.

• 出版日期2013-9