Direct formation of mesoporous upconverting core-shell nanoparticles for bioimaging of living cells

作者：Sun, Lining^*; Liu, Tao; Qiu, Yannan; Liu, Jinliang; Shi, Liyi; Wolfbeis, Otto S.

来源：Microchimica Acta, 2014, 181(7-8): 775-781.

DOI：10.1007/s00604-013-1073-9

• Upconversion nanophosphor
• Mesoporous silica
• Core-shell
• Luminescence imaging
• Biocompatible nanoparticles

We have developed a one-step method for the synthesis of mesoporous upconverting nanoparticles (MUCNs) of the type NaYF4:Yb,Er@mSiO(2) in ammoniacal ethanol/water solution. The mesoporous silica is directly encapsulating the hydrophobic upconversion nanoparticles (UCNs) due to the presence of the template CTAB. Intense green emission (between 520 and 560 nm) and weaker red emission (between 630 and 670 nm) is observed upon 980-nm laser excitation. The MUCNs display low cytotoxicity (as revealed by an MTT test) and were successfully applied to label and image human nasopharyngeal epidermal carcinoma (KB) cells.

• 出版日期2014-6
• 单位上海大学