A comparative cellular and molecular biology of longevity database

作者：Stuart Jeffrey A^*; Liang Ping; Luo Xuemei; Page Melissa M; Gallagher Emily J; Christoff Casey A; Robb Ellen L

来源：Age, 2013, 35(5): 1937-1947.

DOI：10.1007/s11357-012-9458-y

• Life span
• Database
• DNA repair
• Protein homeostasis
• Antioxidant enzymes
• Stress resistance

Discovering key cellular and molecular traits that promote longevity is a major goal of aging and longevity research. One experimental strategy is to determine which traits have been selected during the evolution of longevity in naturally long-lived animal species. This comparative approach has been applied to lifespan research for nearly four decades, yielding hundreds of datasets describing aspects of cell and molecular biology hypothesized to relate to animal longevity. Here, we introduce a Comparative Cellular and Molecular Biology of Longevity Database, available at (%26lt;ExternalRef%26gt; %26lt;RefSource%26gt;http://genomics.brocku.ca/ccmbl/%26lt;/RefSource%26gt; %26lt;RefTarget Address=%26quot;http://genomics.brocku.ca/ccmbl/%26quot; TargetType=%26quot;URL%26quot;/%26gt; %26lt;/ExternalRef%26gt;), as a compendium of comparative cell and molecular data presented in the context of longevity. This open access database will facilitate the meta-analysis of amalgamated datasets using standardized maximum lifespan (MLSP) data (from AnAge). The first edition contains over 800 data records describing experimental measurements of cellular stress resistance, reactive oxygen species metabolism, membrane composition, protein homeostasis, and genome homeostasis as they relate to vertebrate species MLSP. The purpose of this review is to introduce the database and briefly demonstrate its use in the meta-analysis of combined datasets.

• 出版日期2013-10