DruGeVar: An Online Resource Triangulating Drugs with Genes and Genomic Biomarkers for Clinical Pharmacogenomics

作者：Dalabira Eleni; Viennas Emmanouil; Daki Elisavet; Komianou Angeliki; Bartsakoulia Marina; Poulas Konstantinos; Katsila Theodora; Tzimas Giannis; Patrinos George P^*

来源：Public Health Genomics, 2014, 17(5-6): 265-271.

DOI：10.1159/000365895

• Databases
• Data interpretation
• Data querying
• Drug
• Gene
• Pharmacogenomics

Background/Aims: Pharmacogenomics aims to rationalize drug use by minimizing drug toxicity and/or by increasing drug efficacy. A large number of genomic markers have been correlated with variable drug responses and severity of adverse drug reactions. Although a number of these drugs bear pharmacogenomic information in their labels - approved by regulatory agencies - and comprehensive drug/gene lists exist online, information related to the respective pharmacogenomic biomarkers is currently missing from such lists. Methods: We extracted information from the published literature and online resources and developed DruGeVar (http://drugevar.genomicmedicinealliance.org), an online resource triangulating drugs with genes and pharmacogenomic biomarkers in an effort to build a comprehensive database that could serve clinical pharmacogenomics. Results and Conclusions: A user-friendly data querying and visualization interface allows users to formulate simple and complex queries. Such a database would be readily applicable as a stand-alone resource or a plug-in module for other databases.

• 出版日期2014