Direct Prenylation of Aromatic and alpha,beta-Unsaturated Carboxamides via Iridium-Catalyzed C-H Oxidative Addition-Allene Insertion

作者：Zhang Yong Jian; Skucas Eduardas; Krische Michael J^*

来源：Organic Letters, 2009, 11(18): 4248-4250.

DOI：10.1021/ol901759t

Exposure of aromatic carboxamides 1e-1m, heteroaromatic carboxamides in-1p, and alpha,beta-unsaturated carboxamides 1q-1s to 1,1-dimethylallene in the presence of the a cationic iridium complex derived from [Ir(cod)(2)]BAr(4)(F) and rac-BINAP results in direct C-H prenylation to furnish adducts 2e-2m, 2n-2p, and 2q-2s, respectively, in good isolated yields as single isomers.

• 出版日期2009-9-17