ABCB1 C3435T Polymorphism Influences the Risk for Alzheimer%26apos;s Disease

作者：Feher Agnes^*; Juhasz Anna; Pakaski Magdolna; Kalman Janos; Janka Zoltan

来源：Journal of Molecular Neuroscience, 2014, 54(4): 826-829.

DOI：10.1007/s12031-014-0427-z

• Alzheimer%26apos
• s disease
• ATP-binding cassette subfamily B member 1 (ABCB1)
• P-glycoprotein (P-gp)
• Single nucleotide polymorphism (SNP)
• rs1128503 (C1236T)
• rs2032582 (G2677T/A)
• rs1045642 (C3435T)

To evaluate the association of ATP-binding cassette subfamily B member 1 (ABCB1) genetic variants with the susceptibility to Alzheimer%26apos;s disease (AD), we genotyped the rs1128503 (C1236T), rs2032582 (G2677T/A), and rs1045642 (C3435T) polymorphisms in a case-control sample (234 AD patients, 225 controls). Single-marker analyses revealed a significant association solely for the rs1045642 polymorphism (C/C genotype carriers had increased risk for AD), which remains significant after correction for multiple testing. Haplotype analyses indicated three nominally significant associations which were lost after applying multiple test correction.

• 出版日期2014-12