Asymmetric Assembly of Steroidal Tetracyclic Skeletons

作者：Gupta Preeti^*; Panda Gautam

来源：European Journal of Organic Chemistry, 2014, 2014(36): 8004-8019.

DOI：10.1002/ejoc.201402822

• Synthetic methods
• Asymmetric synthesis
• Total synthesis
• Steroids
• Chiral pool

Steroids have long played a vital role in organic synthesis because of their unique structural motif and associated biological properties. In recent years, asymmetric synthesis has emerged as a powerful tool for assembling the tetracyclic framework with high levels of molecular diversity. This review summarizes the latest developments in the enantioselective syntheses of both natural and synthetic steroids incorporating the carbocyclic skeleton. The approaches to the synthesis of steroids and related molecules are based primarily on the use of chiral starting materials, the employment of reagent-controlled asymmetric induction assisted by chiral complexes, chiral Lewis acids or organocatalysts, or the utilisation of chiral auxiliaries.

• 出版日期2014-12