Differences in sequential posttreatment salivary IL-6 levels between patients with and patients without locoregional recurrences of oral squamous cell carcinoma: Part III of a cohort study

作者：Sato Jun^*; Ohuchi Manabu; Wada Mayumi; Ohga Noritaka; Asaka Takuya; Yoshikawa Kazuhito; Miyakoshi Masaaki; Hata Hironobu; Satoh Akira; Kitagawa Yoshimasa

来源：Oral Surgery Oral Medicine Oral Pathology Oral Radiology, 2015, 120(6): 751-760.

DOI：10.1016/j.oooo.2015.08.016

Objective. Sequential postoperative salivary interleukin-6 (IL-6) concentrations were examined in patients with oral squamous cell carcinoma (OSCC) who had early or late locoregional recurrences or those who did not.
Study Design. Twenty-seven consecutive patients with OSCC were originally included in the study. All patients underwent radical surgery. Four saliva samples were collected before (periods I and II) and after (periods III and IV) surgery, and IL-6 concentrations were measured.
Results. Although postoperative (period III: at the time of discharge) salivary IL-6 level was significantly higher in patients with early locoregional recurrence (P = .02) than in those without, no such relationships were observed for preoperative IL-6 concentrations (periods I and II). Postoperative (period IV: 24 months after surgery) IL-6 level was significantly higher in patients with late locoregional recurrence (P = .03) than in those without, but no such relationships were observed for IL-6 concentrations in periods I, II, and III.
Conclusions. Sequential postoperative salivary IL-6 concentration may be a useful marker for diagnosis of early and late locoregional recurrence in OSCC.

• 出版日期2015-12