Association between non-dipper blood pressure behavior and serum calcium fractions inhypertensive patients with mild to moderate chronic renal dysfunction

作者：Feldstein Carlos A; Akopian Maia^*; Olivieri Antonio O; Garrido Delia

来源：Revista de Nefrologia Dialisis y Trasplante, 2012, 32(3): 127-138.

Objectives: To Determine the association between total serum calcium (tCa) and ionic calcium (iCa), with MAPA measurements in hypertensive patients with early renal failure.
Methods: 231 hypertensive patients stages 1-3 of chronic kidney disease (CKD) were included. 24 Hr arterial pressure (AP) was determined by MAPA.
Results: in non-clippers, the prevalence of Cr.Cl. <60 ml/mins/1.73 m2 was greater than in dippers (p<0.02). Covariance analysis showed that in stage 3 of K/DOQI, tCa was less in non-dippers than dippers (9.03 +/- 0.66 vs. 9.41 +/- 1 mg/dL, p<0.02). In non-dippers, there were significant correlations between iCa and 24 hr- systolic AP (SAP)(r = 0.21, p < 0.03), diurnal SAP (r = 0.21, p < 0.03) and 24hr-PP(r=0.23; p<0, 02). Nondippers showed a greater prevalence of the 24 Hr-PP in the highest tertile than dippers. Patients with Cr.Cl. >= 60 mL/min/1, 73 m2 have less propensity to present non-dipper patterns than patients with Clcr<60 mL/min/1, 73 m2 (OR 2.44, IC 95% 1.39-4.27, p < 0.002).

• 出版日期2012-9