Asymmetric domino Michael-aldol reactions catalyzed by recyclable PEG supported chiral primary aminoalcohol and primary-secondary diamine catalysts in water

作者：Pan Xiaoyan; Lu Cuifen; Nie Junqi; Chen Zuxing; Yang Guichun^*; Dong Nianguo; Shi Jiawei

来源：Catalysis Communications, 2014, 53: 72-76.

DOI：10.1016/j.catcom.2014.04.003

• PEG
• Supported
• Aminoalcohol
• Diamine
• Michael-aldol reaction
• Water

PEG supported chiral primary aminoalcohol and primary-secondary diamine have been synthesized and used to catalyze the asymmetric domino Michael-aldol reactions of benzyl benzoylacetate and alpha,beta-unsaturated ketones in water to afford optically active cyclohexanones. Excellent diastereoselectivities, good to excellent enantioselectivities and good yields were obtained, and catalyst recycling was accompanied by almost intact diastereo- and enantioselectivity and some loss of the chemical efficiency.

• 出版日期2014-8-5
• 单位湖北大学