Deracemization of Amino Acids by Partial Sublimation and via Homochiral Self-Organization

作者：Tarasevych Arkadii V; Sorochinsky Alexander E; Kukhar Valery P; Guillemin Jean Claude^*

来源：Origins of Life and Evolution of the Biosphere, 2013, 43(2): 129-135.

DOI：10.1007/s11084-013-9333-6

• Amino acid
• Enantioenrichment
• Sublimation
• Homochirality
• Deracemization
• Self-organization

Deracemization of a 50/50 mixture of enantiomers of aliphatic amino acids (Ala, Leu, Pro, Val) can be achieved by a simple sublimation of a pre-solubilized solid mixture of the racemates with a huge amount of a less-volatile optically active amino acid (Asn, Asp, Glu, Ser, Thr). The choice of chirality correlates with the handedness of the enantiopure amino acids-Asn, Asp, Glu, Ser, and Thr. The deracemization, enantioenrichment and enantiodepletion observed in these experiments clearly demonstrate the preferential homochiral interactions and a tendency of natural amino acids to homochiral self-organization. These data may contribute toward an ultimate understanding of the pathways by which prebiological homochirality might have emerged.

• 出版日期2013-4