Molecular Genotyping of HIV-1 Strains from Newly Infected Men Who Have Sex with Men in Harbin, China

作者：Li, Qing-Hai; Wang, Fu-Xiang^*; Yue, Chao; Wang, Jia-Ye; Jin, Gang; Zhang, Chun-Lei; Song, Bo; Lin, Yuan-Long; Li, Hai-Ning; Feng, Shi-Yan; Liu, Shu-Lin

来源：AIDS Research and Human Retroviruses, 2016, 32(6): 595-600.

DOI：10.1089/aid.2016.0028

• POPULATION
• PREVALENCE
• EPIDEMIC

In this study, blood samples from newly HIV-1 infected men who have sex with men (MSM) were collected, and HIV-1 genotypes were identified based on gag p17-p24 and nef gene regions. We found that participants aged from 20 to 40 years old were the major infection group in Harbin. CRF01_AE was the predominant genotype, contributing to 84.7% of HIV-1 infections, followed by subtype B (4.7%), CRF07_BC (3.5%), and subtype B (Thai B, 1.2%). Moreover, five unique recombinant forms (5.9%) were also identified, including genotypes 01B, 01C, and 01/02. The recombinant CRF01_AE/CRF02_AG was first reported in China. These results suggested that current HIV-1 genotype epidemic among MSM in Harbin is more complicated and that intersubtype recombinants have emerged. Therefore, timely regional epidemiological surveillance of HIV-1 genotype and development of prevention measures for new HIV-1 infections among MSM are quite important.

• 出版日期2016-6
• 单位哈尔滨医科大学