Novel rat model of stress urinary incontinence with a retroflexed bladder

作者：Kawamorita Naoki; Kaiho Yasuhiro^*; Nakagawa Haruo; Miyazato Minoru; Matsushita Mabumi; Arai Yoichi

来源：International Urogynecology Journal and Pelvic Floor Dysfunction, 2010, 21(5): 595-601.

DOI：10.1007/s00192-009-1070-z

• Leak point pressure
• Posterior urethrovesical angle
• Rat model
• Sling
• Sneeze
• Stress urinary incontinence

We created a rat model with a retroflexed bladder that mimicked the loss of the posterior urethrovesical angle and compared the results with sham-surgery rats for the establishment of rat models of stress urinary incontinence.
The retroflexed bladder was created by stitching the bladder posteriorly to the psoas muscle. Sneeze-induced urethral pressure response and urethral baseline pressure were measured using a microtip-transducer catheter and leak point pressures induced by sneezing, the Crede maneuver, and the vertical tilt table method were measured via a supra-pubic cystostomy.
In rats with a retroflexed bladder, both urethral pressure response and sneeze-induced leak point pressure were significantly decreased.
A retroflexed bladder may cause stress urinary incontinence by attenuating the sneeze-induced active urethral closure mechanism. Urethral pressure response restored by resumption of the posterior urethrovesical angle would explain why no sling tension is needed to treat the stress urinary incontinence.

• 出版日期2010-5