Asymmetric anti-Prelog reduction of ketones catalysed by Paracoccus pantotrophus and Comamonas sp cells via hydrogen transfer

作者：Lavandera Ivan; Hoeller Brigitte; Kern Alexander; Ellmer Ursula; Glieder Anton; de Wildeman Stefaan; Kroutil Wolfgang^*

来源：Tetrahedron: Asymmetry , 2008, 19(16): 1954-1958.

DOI：10.1016/j.tetasy.2008.08.005

A broad range of ketones including rnethyl-aryl-, methyl-alkyl-, cyclic and sterically hindered ketones were reduced to the corresponding anti-Prelog alcohols with moderate to excellent stereoselectivities by employing lyophilised cells of Paracoccus pantotrophus DSM 11072 and Comamonas sp. DSM 15091 via hydrogen transfer. The reduction equivalents were provided using 2-propanol as a hydride donor. For instance, acetophenone was reduced to the corresponding (R)-enantiomer with >99% ee.

• 出版日期2008-8-22