A meta-analysis of the relationship between MY09B gene polymorphisms and susceptibility to Crohn's disease and ulcerative colitis

作者：Li, Peng; Yang, Xiao-Ke; Wang, Xiu; Zhao, Meng-Qin; Zhang, Chao; Tao, Sha-Sha; Zhao, Wei; Huang, Qing; Li, Lian-Ju; Pan, Hai-Feng; Ye, Dong-Qing^*

来源：Human Immunology, 2016, 77(10): 990-996.

DOI：10.1016/j.humimm.2016.07.008

• Myosin IXB
• Crohn's disease
• Ulcerative colitis
• Meta-analysis
• Polymorphisms

Objective: Both Crohn's disease (CD) and ulcerative colitis (UC) have a complex etiology involving multiple genetic and environmental factors. Multiple UC and CD susceptibility genes have been identified through genome-wide association studies and subsequent meta-analyses. The aim of this meta-analysis was to clarify the impact of MY09B gene polymorphisms on CD and UC risk.
Methods: The PubMed, Elsevier Science Direct and Embase databases were searched to identify eligible studies that were published before October 2014. Data were extracted and pooled crude odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.
Results: A total of 11 studies, containing 3297 CD cases, 3903 UC cases and 8174 controls were included in this meta-analysis. Bonferroni correction results showed that rs1545620 A/C polymorphism of MY09B gene was associated with both CD and UC susceptibility in Caucasians (OR = 0.88, 95% CI = 0.82 similar to 0.95, P = 0.001; OR = 0.82, 95% CI = 0.76 similar to 0.89, P < 0.001), but not in Chinese. rs1457092 G/T and rs2305764 C/T polymorphisms are associated with UC susceptibility (OR = 0.85, 95% CI = 0.79 similar to 0.91, P < 0.001; OR = 0.88, 95% CI = 0.83 similar to 0.93, P < 0.001), but not with CD susceptibility in Caucasians.
Conclusions: This meta-analysis suggested that rs1545620 is both CD and UC susceptible locus in Caucasians; rs1457092 and rs2305764 are UC susceptible loci, but are not CD susceptible loci in Caucasians. Further studies with more sample size are needed for a definitive conclusion.

• 出版日期2016-10
• 单位安徽医科大学; 舟山市疾病预防控制中心