Activities of Oxadiazole Antibacterials against Staphylococcus aureus and Other Gram-Positive Bacteria

作者：Ceballos Sara; Kim Choon; Ding Derong; Mobashery Shahriar; Chang Mayland; Torres Carmen^*

来源：Antimicrobial Agents and Chemotherapy, 2018, 62(8).

DOI：10.1128/AAC.00453-18;e00453-18

• Enterococcus
• MIC
• MRSA
• PBPs
• Staphylococcus spp.
• oxadiazole

The activities of four oxadiazoles were investigated with 210 methicillin-resistant Staphylococcus aureus (MRSA) strains. MIC50 and MIC90 values of 1 to 2 and 4 mu g/ml, respectively, were observed. We also evaluated the activity of oxadiazole ND-421 against other staphylococci and enterococci and in the presence of oxacillin for selected MRSA strains. The MIC for ND-421 is lowered severalfold in combination with oxacillin, as they synergize. The MIC90 of ND-421 against vancomycin-resistant enterococci is <= 1 mu g/ml.

• 出版日期2018-8