A Prospective Multicenter Clinical Trial of Chinese Herbal Formula JZQG (Jiangzhuoqinggan) for Hypertension

作者：Tong, Xiao-Lin; Lian, Feng-Mei^*; Zhou, Qiang; Xu, Li-Peng; Ji, Hang-Yu; Xu, Gui-Cheng; Hu, Yuan-Hui; Zhao, Lin-Hua; Xia, Le; Wang, Jia; Chen, Xin-Yan; Chan, Man-Hon; Zhang, Lan-Lan; Gao, Wen; Zhen, Zhong; Zhou, Shui-Ping; Chang, Bai

来源：American Journal of Chinese Medicine, 2013, 41(1): 33-42.

DOI：10.1142/S0192415X13500031

• Hypertension
• Metabolic Syndrome
• Jiangzhuoqinggan
• JZQG Formula
• Rhubarb
• Coptis
• Cassia
• Uncaria
• Ibrbesartan

A prospective multicenter clinical trial was conducted to compare the beneficial effects of a Chinese herbal medicine formula Jiangzhuoqinggan (JZQG) and western anti-hypertension drug irbesartan. JZQG is mainly composed of rhubarb, coptis, cassia, and uncaria. A total of 240 patients with mild to moderate hypertension were enrolled in the trial. Patients were assigned into two groups after screening: JZQG group and the irbesartan group. After four weeks of treatment, we compared the changes in routine blood pressure, 24 h ambulatory blood pressure, and waist circumference. There was a significant reduction in systolic blood pressure and diastolic blood pressure in the JZQG group (both p < 0: 01). There were no significant differences between the reduction of systolic and diastolic blood pressures in the two treatment groups. From the 24 h ambulatory blood pressure measurement, the JZQG group showed a greater reduction in both systolic and diastolic blood pressures (in both daytime and nighttime) than the irbesartan group. Furthermore, there was a significant difference in waist circumference in the JZQG group (1.51 cm reduction; P < 0: 05) but not the irbesartan group (0.42 cm). Thus, the JZQG formula may have therapeutic value in patients with both hypertension and metabolic syndrome.

• 出版日期2013
• 单位中国中医科学院广安门医院; 天津医科大学; 北京中医药大学; 中国药科大学