A novel terephthalaldehyde based turn-on fluorescent chemosensor for Cu2+ and its application in imaging of living cells

作者：Torawane Pritam; Keshav Karunesh; Kumawat Mukesh K; Srivastava Rohit; Anand Thangaraj; Sahoo Suban; Borse Amulrao^*; Kuwar Anil^*

来源：Photochemical and Photobiological Sciences, 2017, 16(9): 1464-1470.

DOI：10.1039/c7pp00182g

A new terephthaldehyde-based chemosensor 1 bearing an aminophenol recognition unit has been synthesized and applied to the fluorescent sensing of metal ions. Molecular system 1 acts as a highly selective and sensitive fluorescence turn-on sensor for Cu2+. The sensing mechanism has been explored. It is proposed that Cu2+ binds with the imine and hydroxyl moiety of 1 in 1 : 2 binding stoichiometry, thereby enhancing the fluorescence at 386 nm. The detection limit and association constant (K-a) of 1 with Cu2+ were found to be 0.62 mu M and 6.67 x 10(4) M-1, respectively. Chemosensor 1 has shown excellent specificity towards Cu2+ and has been successfully applied to the determination of Cu2+ in live L929 cells.

• 出版日期2017-9-1