Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

作者：Chen, Xinwang; Jia, Xiao; Qiao, Jie; Guan, Youfei; Kang, Jihong^*

来源：Journal of Molecular Endocrinology, 2013, 50(2): R21-R37.

DOI：10.1530/JME-12-0247

• polycystic ovary syndrome
• adipokines
• obesity
• adipose tissue

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy associated with infertility and metabolic disorder in women of reproductive age. Dysfunction of adipose tissue has been implicated in the pathophysiology of PCOS. Increasing evidence shows that the dysregulated expression of adipokines, the secreted products of adipose tissue, plays an important role in the pathology of PCOS. Here, we review the role of several identified adipokines that may act as a link between obesity and PCOS. PCOS also reciprocally influences the profile of adipokines. Insight into the underlying mechanisms will help better understand the pathology of PCOS and identify new therapeutic targets of this syndrome.

• 出版日期2013-4
• 单位北京大学