DEVELOPMENT AND EVALUATION OF MICROEMULSION-BASED HYDROGEL FORMULATIONS FOR TOPICAL DELIVERY OF PROPRANOLOL HYDROCHLORIDE

作者：Olariu I; Coneac G; Vlaia L^*; Vlaia V; Anghel D F; Ilie C; Popoiu C; Lupuleasa D

来源：Digest Journal of Nanomaterials and Biostructures, 2014, 9(1): 395-412.

• Propranolol hydrochloride
• Microemulsion
• Hydrogel
• Topical

The aim of the present investigation was to develop and evaluate microemulsion based hydrogels (MEH) for the topical delivery of propranolol hydrochloride (PRHCl). The solubility of PRHCl in oils, surfactants and cosurfactants was evaluated to identify the components of the microemulsion. The pseudoternary phase diagrams were constructed using the novel Phase Diagram by Micro Plate Dilution method. Carbopol EDT 2020 was used to convert PRHCl loaded microemulsions into gel form without affecting their structure. The selected microemulsions were assessed for globule size, zeta potential, and polidispersity index. Besides this, the MEH-PRHCl formulations were evaluated for drug content, pH, rheological properties and in vitro drug release through synthetic membrane. The optimized MEH-PRHCl formulations consisting of PRHCl 1%, Capryol 90 11% and 12% respectively as oil phase, Cremophor RH 40:propyleneglycol 49% and 53% respectively as surfactant: cosurfactant (2:1) and 1.7% Carbopol EDT 2020, showed high flux value, highest release rate values, shortest lag time values and lowest surfactant content. The in vitro PRHCl permeation through synthetic membrane from the studied MEH was found to follow the Korsmeyer-Pepas model (R-2 > 0.99) with a non-Fickian, "anomalous" release mechanism. The results suggest the potential use of developed MEHs as vehicles for topical delivery of PRHCl.

• 出版日期2014-3