A general strategy for the preparation of C-terminal peptide alpha-ketoacids by solid phase peptide synthesis

作者：Ju Lei; Bode Jeffrey W^*

来源：Organic and Biomolecular Chemistry, 2009, 7(11): 2259-2264.

DOI：10.1039/b901198f

A new cyanosulfur-ylide based linker makes possible the synthesis of C-terminal peptide alpha-ketoacids by solid phase synthesis. The preparation of the requisite linker and its application to a variety of C-terminal peptide alpha-ketoacids with unprotected side chains is reported.

• 出版日期2009