Dual-functional probes towards in vivo studies of brain connectivity and plasticity

作者:Mamedov Ilgar*; Engelmann Joern; Eschenko Oxana; Beyerlein Michael; Logothetis Nikos K
来源:Chemical Communications, 2012, 48(22): 2755-2757.
DOI:10.1039/c1cc15991g

摘要

A Gd3+ based paramagnetic dextran conjugate has been developed, which enables the tracking of neuroanatomical connectivity in the brain by both MR and optical imaging. Cell studies and subsequent in vivo experiments in rodents demonstrate efficient internalisation and transport properties of the new tracer molecule.

  • 出版日期2012