Maintenance of mitochondrial DNA by the Caenorhabditis elegans ATR checkpoint protein ATL-1

作者：Mori Chihiro; Takanami Takako; Higashitani Atsushi^*

来源：GENETICS, 2008, 180(1): 681-686.

DOI：10.1534/genetics.108.090704

Here we show that inactivation of the ATR-related kinase ATL-1 results in a significant reduction in mitochondrial DNA (mtDNA) copy numbers in Caenorhabditis elegans. Although ribonucleotide reductase (RNR) expression and the ATP/dATP ratio remained unaltered in alt-1 deletion mutants, inhibition of RNR by RNAi or hydroxyurea treatment caused further reduction in mtDNA independently of RNR.

• 出版日期2008-9