Molecular mechanisms for plasmacytoid dendritic cell function and development

作者：Kaisho Tsuneyasu^*

来源：Vaccine, 2010, 28(50): 8046-8047.

DOI：10.1016/j.vaccine.2010.09.025

• Dendritic cell
• Plasmacytoid dendritic cell
• Toll-like receptor
• I kappa B kinase
• Type I interferon

Dendritic cells (DCs) are activated by immune adjuvants in a DC subset-specific manner. Plasmacytoid DC (pDC) is a unique subset that senses nucleic acid immune adjuvants only through two Toll-like receptors (TLRs), TLR7 and TLR9 and produces large amounts of type I interferons. Here 1 review recent trend in pDC function and development.

• 出版日期2010-11-23