Asymmetric Formation of Bridged Benzoxazocines through an Organocatalytic Multicomponent Dienamine-Mediated One-Pot Cascade

作者：Ran**org Lars Krogager; Overgaard Mette; Hejmanowska Joanna; Barfusser Sebastian; Jorgensen Karl Anker^*; Albrecht Lukasz

来源：Organic Letters, 2014, 16(16): 4182-4185.

DOI：10.1021/ol501882x

An organocatalytic one-pot cascade leading to the stereoselective formation of novel bridged benzoxazocines is presented. The developed methodology is based on the first example of a gamma-selective-Mannich-initiated cascade reaction and allows for direct annulation of the bridged benzoxazocines by incorporation of various alpha,beta-unsaturated aldehydes, electron-rich anilines, and electron-deficient salicylaldehydes. The synthetic applicability of the products is demonstrated by relevant transformations.

• 出版日期2014-8-15