Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella

作者：Kovatcheva-Datchary, Petia; Nilsson, Anne; Akrami, Rozita; Lee, Ying Shiuan; De Vadder, Filipe; Arora, Tulika; Hallen, Anna; Martens, Eric; Bjorck, Inger; Backhed, Fredrik^*

来源：Cell Metabolism, 2015, 22(6): 971-982.

DOI：10.1016/j.cmet.2015.10.001

• GUT MICROBIOTA
• XYLAN DEGRADATION
• METAGENOME
• BACTERIAL
• TOLERANCE
• DIVERSITY
• OBESITY
• IMPACT
• GI

The gut microbiota plays an important role in human health by interacting with host diet, but there is substantial inter-individual variation in the response to diet. Here we compared the gut microbiota composition of healthy subjects who exhibited improved glucose metabolism following 3-day consumption of barley kernel-based bread (BKB) with those who responded least to this dietary intervention. The Prevotella/Bacteroides ratio was higher in responders than non-responders after BKB. Metagenomic analysis showed that the gut microbiota of responders was enriched in Prevotella copri and had increased potential to ferment complex polysaccharides after BKB. Finally, germ-free mice transplanted with microbiota from responder human donors exhibited improved glucose metabolism and increased abundance of Prevotella and liver glycogen content compared with germ-free mice that received non-responder microbiota. Our findings indicate that Prevotella plays a role in the BKB-induced improvement in glucose metabolism observed in certain individuals, potentially by promoting increased glycogen storage.

• 出版日期2015-12-1