科研之友
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摘要
Myocardial Infarction may be cited as foremost reasons of death all over the world. Isoproterenol is a synthetic catecholamine which is reported to cause myocardial infarction in adult rats in various researches. Squalene is an isoprenoid; a derivative from shark liver oil is informed to have antioxidant, antiperoxidant and membrane stabilizing properties. Our study prepares squalene loaded gold nanoparticles as an attempt for therapeutics of myocardial infarction in rat model. The squalene loaded gold nanoparticles are small in size ranging from 115-155 nm, benzoid or triangular in shape with roughened edges. The encapsulation efficiency is noted to be 82% and drug loading capacity is 8.78%. They show an early burst release followed by a slow sustained release. This also attunes in providing the cardioprotective mechanism. Squalene loaded nanoparticles demonstrate low cardiotoxicity too since squalene is derived from biological sources. The cytostructural design of the myocardiocytes is maintained with very little changes even after induction of myocardial infarction. Impediametric studies depict that impedance increases for squalene loaded drug nanoparticles treated sample as compared to squalene, gold nanoparticles and control samples. Hence, squalene loaded gold nanoparticles may prove to be a therapeutic alternative in cardiovascular diseases.
- 出版日期2018-2
- 单位郑州大学
