A biocompatible calcium salt of hyaluronic acid grafted with polyacrylic acid

作者：Nakagawa Yoshiyuki; Nakasako Satoshi; Ohta Seiichi; Ito Taichi^*

来源：Carbohydrate Polymers, 2015, 117: 43-53.

DOI：10.1016/j.carbpol.2014.09.037

• Hyaluronic acid
• Polyacrylic acid
• Controlled radical polymerization
• Intraperitoneal administration
• Drug delivery
• Adhesion preventing material

We have synthesized hyaluronic acid (HA) grafted with polyacrylic acid (PAA) via controlled radical polymerization (CRP) in aqueous media. The grafted HA (HA-g-PAA) showed slow degradation by hyaluronidase compared with unmodified HA as a result of the steric hindrance produced by grafted PAA, and PAA was detached by hydrolysis and enzymatic degradation by lipase. It formed an insoluble salt immediately after mixing with Ca2+ by the binding between grafted PAA and Ca2+. Both HA-g-PAA and its salt showed good biocompatibility, especially to mesothelial cells in vitro. Finally, they were administered into mice subcutaneously and intraperitoneally. The residue of the material was observed 7 days after subcutaneous administration, while the material was almost cleared from the peritoneum 7 days after intraperitoneal administration with or without Ca2+. HA-g-PAA is expected to be applicable to medical uses such as drug delivery in the peritoneum and for materials preventing peritoneal adhesion.

• 出版日期2015-3-6