A novel marker in acute central serous chorioretinopathy: thiol/disulfide homeostasis

作者：Altinkaynak Hasan^*; Kurkcuoglu Piraye Zeynep; Caglayan Mehtap; Yorgun Mucella Arikan; Yuksel Nilay; Kosekahya Pinar; Koca Cemile; Toklu Yasin

来源：International Ophthalmology, 2018, 38(1): 175-181.

DOI：10.1007/s10792-017-0444-3

• Central serous chorioretinopathy
• Total thiol
• Native thiol
• Thiol/disulfide ratio

Purpose The aim of this study was to compare dynamic thiol/disulfide homeostatic status in acute central serous chorioretinopathy (CSCR) patients by using a novel and automated assay determining dynamic thiol/disulfide homeostasis.
Methods Fifty-one patients with acute CSCR (study group) and 65 healthy individuals (control group) were enrolled in this study. Diagnosis of acute CSCR was made clinically and using spectral-domain RTVue OCT (optical coherence tomography) (Optovue, Fremont, CA). Fluorescein angiography confirmed the diagnosis of acute CSCR in all subjects. Total thiol, native thiol, disulfide amount, and native thiol/disulfide ratio (TDR) were calculated in the blood samples.
Results Mean total thiol, native thiol, and native TDR values were lower in patients with acute CSCR (364.2 +/- 14.1, 326.4 +/- 13.2, 17.14 +/- 1.9, respectively) than in healthy eyes (441.2 +/- 16.3, 398.5 +/- 16.4, 22.70 +/- 2.15, respectively; mean total thiol, p = 0.017; native thiol, p = 0.011; native TDR, p = 0.031).
Conclusions Total thiol, native thiol, and native TDR were significantly lower statistically in patients with acute CSCR when compared with healthy controls.

• 出版日期2018-2