A total synthesis of (R,S)(S)-glucoraphanin

作者：Vo Quan V; Trenerry Craige; Rochfort Simone; Hughes Andrew B^*

来源：Tetrahedron, 2013, 69(41): 8731-8737.

DOI：10.1016/j.tet.2013.07.097

• Glucoraphanin
• Sulforaphane
• Sulfinylalkyl glucosinolates
• Glucosinolates
• Brassica

A total synthesis of (R,S)(S)-glucoraphanin (GRP) has been completed by a novel, simple and convenient method in high overall yield (17% over seven steps). The study describes a method for the synthesis of natural and unnatural (methylsulfinyl)alkyl glucosinolates (GLs) and also opens useful pathways to synthesize GRP as well as other sulfinyl GLs.

• 出版日期2013-10-14