Anti-AGEs and antiparasitic activity of an original prenylated isoflavonoid and flavanones isolated from Derris ferruginea

作者：Morel Sylvie; Hele**eux Jean Jacques; Seraphin Denis; Derbre Severine; Gatto Julia; Aumond Marie Christine; Abatuci Yannick; Grellier Philippe; Beniddir Mehdi A; Le Pape Patrice; Pagniez Fabrice; Litaudon Marc; Landreau Anne^*; Richomme Pascal

来源：Phytochemistry Letters, 2013, 6(3): 498-503.

DOI：10.1016/j.phytol.2013.06.002

• Derris ferruginea
• Fabaceae
• Flavonoid
• Synthesis
• Antiparasitic
• AGEs (advanced glycation endproducts)

A new isoflavonoid, 5-hydroxy-3-(4-hydroxyphenyl)-8-isopropenyl-8,9-dihydro-4H-furo-[2,3-h]-chromen-4-one named derrisisoflavone G (1), four known prenylated flavanones (2-5), four known isoflavonoids (6-9) and two phenolic derivatives (10, 11) have been isolated from crude extracts of Derris ferruginea stems and leaves. Compounds 1-11 were identified using spectroscopic methods whereas an unambiguous structural assignment of 1 was accomplished through hemi-synthesis. Compounds 2-5 exhibited strong in vitro antiparasitic activity against Plasmodium falciparum and Leishmania major but with poor selectivity, whereas 1-5 significantly inhibited the formation of advanced glycation endproducts (AGEs).

• 出版日期2013-8