Development of renal cell carcinoma (RCC) diagnostics and impact on prognosis

作者：Sunela Kaisa L^*; Lehtinen Eero T; Kataja Matti J; Kujala Paula M; Soimakallio Seppo; Kellokumpu Lehtinen Pirkko Liisa I

来源：BJU International, 2014, 113(2): 228-235.

DOI：10.1111/bju.12242

• carcinoma
• renal cell
• diagnostics
• prognosis

Objective %26lt;br%26gt;To evaluate imaging methods and prognoses between small renal cell carcinomas (RCCs) and larger tumours according to the era of diagnostics. %26lt;br%26gt;Patients and Methods %26lt;br%26gt;In all, 784 consecutive patients diagnosed with RCC between 1964 and 1997 at the Pirkanmaa Hospital District in Finland were included. %26lt;br%26gt;Patients were divided into two groups: tumours of 3.0 and %26gt;3.0cm in diameter. %26lt;br%26gt;Prognosis was analysed according to the era of diagnostics: (i) pre-computed tomography (CT) and pre-ultrasound (US), (ii) US era and (iii) CT era. %26lt;br%26gt;Results %26lt;br%26gt;Small tumours became more common: in the pre-CT and pre-US era, only 4.4% of tumours were small; however, in the CT era 16% were small tumours. %26lt;br%26gt;More diagnostic methods were used in studying small tumours. %26lt;br%26gt;CT proved to be the most reliable method, although it was actually better at diagnosing large tumours. %26lt;br%26gt;Relapses occurred less frequently among patients with small tumours; more than half of the tumours that developed distant metastases (16.0%) already evinced them at the time of diagnosis. There were no relapses after 14 years of follow-up among small tumours, whereas large tumours relapsed within that time. RCC was the cause of death in 14.9% of patients with small tumours vs 50.7% with large tumours. %26lt;br%26gt;The best prognosis was among patients with small tumours diagnosed with CT. %26lt;br%26gt;Conclusion %26lt;br%26gt;Among patients with small tumours, prognosis has improved along with better diagnostics, although some showed relapse during a surveillance period of up to 14 years.

• 出版日期2014-2