Antioxidant and antibacterial constituents from Morus nigra

作者：Mazimba Ofentse^*; Majinda Runner R T; Motlhanka Daniel

来源：African Journal of Pharmacy and Pharmacology, 2011, 5(6): 751-754.

• Morus nigra
• antioxidant
• antibacterial
• oxyresveratrol
• isoprenylated flavonoids

The objective of this study was to isolate and characterize the constituents of the local Morus nigra L. (Black mulberry), to compare its constituents with other studied Mulberries and to evaluate its antioxidative and anti-bacterial activities. The isolated compounds were identified by comparison of spectral data (UV, IR, MS and NMR) with literature values. The stem bark and wood of M. nigra yielded a stilbenoid oxyresveratrol 1, a 2-arylbenzofuran moracin M2, four isoprenylated flavonoids; cyclomorusin 3, morusin 4, kuwanon C5 and a derivative of kuwanon C6, two tritepenes; betulinic acid 7, a-amyrin acetate 8 and a steroidal saponin beta-sitosterol-3-O-beta-D-glucoside 9. The phenolic isolates showed moderate DPPH radical scavenging activity (EC(50) = 23-135 mu gml(-1)) compared to ascorbic acid (EC(50) = 41 mu gml(-1)) after 30 min. Compounds 1, 2 and 4 to 6 showed activities against Staphylococcus aureus, Bacillus subtilis, Micrococus flavus, Streptococcus faecalis, Salmonella abony, Pseudomonas aeruginosa.

• 出版日期2011-6