Autologous nerve segment-bridging regeneration chambers for the repair of sciatic nerve defects

作者：Zhang, Jiren^*; Cao, Changsong; Zhang, Jincheng

来源：Neural Regeneration Research, 2011, 6(4): 262-266.

DOI：10.3969/j.issn.1673-5374.2011.04.004

• nerve segment
• regeneration chamber bridging
• sciatic nerve defect
• neural regeneration

Proximal and distal nerve defects exhibit chemotactic growth over certain distances. Our previous studies demonstrated that Schwann cells survive in autologous nerve segments that are bridged by regeneration chambers and secrete various bioactive substances. However, more data are required to determine the required length of regeneration chambers for chemotaxis and nutrition of neural regeneration, as well as the length of repaired nerve defects to replace the effect of autologous nerve grafting. In the present study, sciatic nerve defects of 12, 16, 20 mm were repaired using a regeneration chamber of 6, 8, and 10 mm in length respectively. These were bridged with autologous nerve segments. Results showed that the bridging of two 6-mm long regeneration chambers to repair a 12-mm nerve defect exhibited similar effects to autologous nerve grafting.

• 出版日期2011-2-5
• 单位锦州医科大学