Abrogation of the Interferon Response Promotes More Efficient Human Cytomegalovirus Replication

作者：McSharry Brian P; Forbes Simone K; Avdic Selmir; Randall Richard E; Wilkinson Gavin W G; Abendroth Allison; Slobedman Barry^*

来源：Journal of Virology, 2015, 89(2): 1479-1483.

DOI：10.1128/JVI.02988-14

The effect of abrogating the interferon (IFN) response on human cytomegalovirus (HCMV) replication was investigated using primary human cells engineered to block either the production of or the response to type I IFNs. In IFN-deficient cells, HCMV produced larger plaques and spread and replicated more rapidly than in parental cells. These cells demonstrate the vital role of IFNs in controlling HCMV replication and provide useful tools to investigate the IFN response to HCMV.

• 出版日期2015-1