An efficient synthesis of brominated 4-alkyl-2(5H)-furanones

作者：Iskander George; Zhang Ruonan; Chan Daniel Shiu Hin; Black David Stc; Alamgir Mahiuddin; Kumar Naresh^*

来源：Tetrahedron Letters, 2009, 50(32): 4613-4615.

DOI：10.1016/j.tetlet.2009.05.105

• Furanone
• Fimbrolide
• Cyclodehydration
• Quorum sensing inhibitor

A versatile method for the synthesis of novel brominated 4-alkyl-2(5H)-furanones under mild reaction conditions is described. This synthetic strategy requires only one chromatographic separation over six steps and employs the cyclodehydration of brominated levulinic acid as the key transformation.

• 出版日期2009-8-12